Title:
生物学的実体の固定方法の改善
Document Type and Number:
Japanese Patent JP7365371
Kind Code:
B2
Abstract:
According to the invention there is provided inter alia a process for the manufacture of a solid object having a surface comprising a layered coating of cationic and anionic polymer wherein the outer coating layer comprises an anticoagulant entity, comprising the steps of:i) treating a surface of the solid object with a cationic polymer;ii) treating the surface with an anionic polymer;iii) optionally repeating steps i) and ii) one or more times;iv) treating the surface with a cationic polymer; andv) treating the outermost layer of cationic polymer with an anticoagulant entity, thereby to covalently attach the anticoagulant entity to the outermost layer of cationic polymer; wherein, the anionic polymer is characterized by having (a) a total molecular weight of 650 kDa-10,000 kDa; and (b) a solution charge density of >4 μeq/g; and wherein, step ii) is carried out at a salt concentration of 0.25 M-5.0 M.
Inventors:
Per Antoni
Marin Ericsson
Anna Garlhagen
Eva Cork
Daniel Nystrom
Christian Porsche-Graham
Helena Goransson
Marin Ericsson
Anna Garlhagen
Eva Cork
Daniel Nystrom
Christian Porsche-Graham
Helena Goransson
Application Number:
JP2020570643A
Publication Date:
October 19, 2023
Filing Date:
March 08, 2019
Export Citation:
Assignee:
Carmeda AB
International Classes:
B32B27/00; A61K31/727; A61L31/04; A61L31/10; A61L31/12; A61L31/14; A61L31/16; A61L33/00; A61L33/10; A61P7/02; C08J7/04
Domestic Patent References:
| JP2016193202A | ||||
| JP58149915A | ||||
| JP2014508610A | ||||
| JP2012502678A | ||||
| JP2016220701A | ||||
| JP2018521086A |
Foreign References:
| US20180028713 | ||||
| US20140135285 |
Attorney, Agent or Firm:
Toru Ishikawa