Title:
IN VITRO RENAL TUBULAR TISSUE SYSTEM
Document Type and Number:
Japanese Patent JP3795900
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a bio-artificial kidney device for providing a growth means in vitro in a transplantable renal tubular cell for avoiding the necessity of a long-term dialytic treatment as a result of substituting the kidney function for imparting a large profit to an ESRD patient by lengthening the remaining life of a patient, increasing the movement and flexibility, enhancing quality of life, reducing a danger of infection, and reducing treatment cost.
SOLUTION: This in vitro renal tubular tissue system is prepared by a process including cultivation of nephrocyte of an adult in the presence of any one of a retinol acid, an epithelium growth factor or a transforming growth factor-β. The tube formation is phenotype transformation of a cell performed so as to partition a lumen by a cell having a polarized epithelium phenotype and a tight junctional complex running along a lumen boundary by generating a concentrated agglomerate of a tubule cell around the center of the lumen. The bio-artificial kidney device uses this in vitro renal tubular tissue system.
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Inventors:
Fumes, David H.
Sheslinsky, Deborah A..
Sheslinsky, Deborah A..
Application Number:
JP2004161578A
Publication Date:
July 12, 2006
Filing Date:
May 31, 2004
Export Citation:
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
International Classes:
A61L27/00; A61F2/02; C12N15/09; A61K31/20; A61K31/557; A61K31/57; A61K33/12; A61K33/24; A61K38/22; A61K48/00; A61M1/14; A61M1/18; A61P13/02; A61P15/00; C12M3/06; C12N5/00; C12N5/02; C12N5/071; C12N5/074; C12N5/10; C12N15/63; C12N15/85; A61K35/12; (IPC1-7): A61L27/00; A61M1/14
Foreign References:
| WO1993017696A1 |
Other References:
Yang, J., et al.,Proc. Natl. Acad. Sci.,1979年,Vol.76, No. 7,pp. 3401-3405
Attorney, Agent or Firm:
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Hiromi Matoba
Toshio Takano
Toshio Nakajima
Hiromi Matoba