IN VIVO DETECTION OF APOPTOSIS

Japanese Patent JP2013165729

A

To provide a method and product for in vivo determination of the apoptotic state of cells in an organism.

This invention provides a method and product, such as kits, useful for determining the apoptotic state of cells in an organism, including detecting the presence or abundance of at least one caspase affinity labeling agent in the cells of an animal into which at least one caspase affinity labeling agent has been introduced, wherein the presence or abundance of the caspase affinity labeling agent correlates with the apoptotic state of the cells. Another embodiment of this invention provides an in vivo diagnostic method for determining the presence or absence of a disease characterized by the presence of apoptosis. The diseases include, but are not limited to, glaucoma, retinal macular degeneration, proliferative retinopathy, neuropathy, Alzheimer's disease, multiple sclerosis, Huntington's disease and others, and cardiac diseases.

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JOHNSON GARY
LEE BRIAN W

JP2013094397A

August 29, 2013

April 26, 2013

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IMMUNOCHEMISTRY TECHNOLOGIES LLC

C12Q1/02

JP2003531871A	2003-10-28
JP2002506829A	2002-03-05

JPN6011068899; Ｌａｘｍａｎ，Ｂ．，ｅｔ　ａｌ．: '"Ｎｏｎｉｎｖａｓｉｖｅ　ｒｅａｌ-ｔｉｍｅ　ｉｍａｇｉｎｇ　ｏｆ　ａｐｏｐｔｏｓｉｓ"' Ｐｒｏｃ．　Ｎａｔｌ．　Ａｃａｄ．　Ｓｃｉ．　ＵＳＡ Ｖｏｌ．９９，Ｎｏ．２６, 20021224, Ｐ．１６５５１-１６５５５

Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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