Title:
バチルスにおけるタンパク質発現の増大
Document Type and Number:
Japanese Patent JP5170793
Kind Code:
B2
Abstract:
The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.
Inventors:
Ferrari, Eugenio
Harbison, Carroll
Rashid, M Harnuour
Wailer, Walter
Harbison, Carroll
Rashid, M Harnuour
Wailer, Walter
Application Number:
JP2010183904A
Publication Date:
March 27, 2013
Filing Date:
August 19, 2010
Export Citation:
Assignee:
Genenco International Inc.
International Classes:
C12N1/21; C12N15/09; C07K14/32; C12N9/12; C12N9/16; C12N9/18; C12N9/20; C12N9/26; C12N9/42; C12N9/54; C12N9/56; C12N9/88; C12N9/90; C12N15/75; C12R1/07; C12R1/08; C12R1/10; C12R1/11; C12R1/125
Domestic Patent References:
| JP6507075A |
Other References:
J. Bacteriol., 1999年12月, vol. 181, no. 23, p. 7346-7355
J. Bacteriol., 170[6](1988) p.2560-2567
J. Bacteriol., 170[6](1988) p.2560-2567
Attorney, Agent or Firm:
Takeko Miko
Yuzo Yamazaki
Yuzo Yamazaki
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