INDANNACETIC ACID AMINO ESTER AND ITS MANUFACTURE

Title:

INDANNACETIC ACID AMINO ESTER AND ITS MANUFACTURE

Document Type and Number:

Japanese Patent JPS5519279

Kind Code:

A

Abstract:

2-(5-Indanyl)propionate esters of formula (where R 2 Et or i-Pr) (I) and their acid-addn. and quat. ammonium salts are new. (I) are prepd. by reacting a cpd. of formula (II) with a cpd. of formula (III) (where Q is OM (M = metal) and Z is CH2CH2Y (Y=halogen), or Q is halogen and Z is CH2CH2OH or Q is OCH2CH2Y and Z is H). (I) have analgesic activity and low toxicity, e.g. (I,R=Et) has an analgesic ED50 of 4 mg/kg (p.o. mouse) and a LD50 of >512 mg/kg (i.p. mouse).

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Inventors:

JIYAN MARII TEYURON

Application Number:

JP9330879A

Publication Date:

February 09, 1980

Filing Date:

July 24, 1979

Export Citation:

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Assignee:

HEXACHIMIE

International Classes:

C07D295/08; A61K31/495; A61P25/04; C07C51/60; C07D295/088; (IPC1-7): A61K31/495; C07D295/08

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