PURPOSE: To obtain an indazole derivative excellent in calmodulin inhibiting action, anti-hypoxia action, having strong brain protecting action and especially useful as a preventing and treating agent for hypertonic, ischemic diseases, etc.
CONSTITUTION: This indazole derivative is expressed by formula I [G is a 1-6C alkyl, phenyl, benzoyl, α-hydroxybenzyl, etc.; R1 and R2 are each a 1-6C alkyl, a 1-6C alkoxyl, trifluoromethyl, etc.; R' is a group of the formula (CH2)n-Y [(n) is 1, 2 or 3; Y is carboxyl, an alkoxycarbonyl, hydroxyl, etc.]. The compound of formula I is obtained by reacting, e.g. a compound of formula II [R is an alkyl; (m) is 0, 1 or 2] with a reducing agent and reacting the resultant compound with G-L1 (G is a residue after removal of H atom from above G; L1 is an eliminable group). A compound of formula III (Z is a single bond, etc.) is reacted with a compound of formula IV (Q is an aryl, a heterocyclic group, etc.) and the resultant product is reduced to provide a piperazine derivative of formula V.
MAKINO TORU
YAMAMOTO KENJIRO
