Title:
インダゾールキナーゼ阻害剤及びその使用
Document Type and Number:
Japanese Patent JP7176798
Kind Code:
B2
Abstract:
The present invention relates to a kinase inhibitor, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention further relates to pharmaceutical compositions comprising the kinase inhibitor, as well as to using said compounds and compositions to inhibit cKIT (especially mutant cKIT/T670I), FLT3 (comprising mutant FLT3-ITD), PDGFRa⊥, PDGFRa┬, and/or VEGFR2 kinase activity in cells or a subject, and/or to a use and method for preventing or treating disorders related to cKIT (especially mutant cKIT/T670I), FLT3 (comprising mutant FLT3-ITD), PDGFR3⊥, PDGFRa┬, and/or VEGFR2 activity in a subject. (I)
Inventors:
▲劉▼ 静
▲劉▼ 青松
▲劉▼ 学松
王 ▲ベイ▼蕾
▲陳▼ 程
▲斉▼ 紫平
Wang Wen Super
Toshiki Wang
▲蒋▼ 宗儒
Fumiaki Mio
▲其▼ 爽
King Rei
▲劉▼ 青松
▲劉▼ 学松
王 ▲ベイ▼蕾
▲陳▼ 程
▲斉▼ 紫平
Wang Wen Super
Toshiki Wang
▲蒋▼ 宗儒
Fumiaki Mio
▲其▼ 爽
King Rei
Application Number:
JP2021523586A
Publication Date:
November 22, 2022
Filing Date:
November 12, 2018
Export Citation:
Assignee:
安徽中科拓苒▲薬▼物科学研究有限公司
International Classes:
A61K31/4439; A61K31/444; A61K31/4545; A61K31/496; A61K31/506; A61P1/00; A61P35/00; A61P43/00
Domestic Patent References:
| JP2013526542A |
Attorney, Agent or Firm:
Takafumi Masui
Atsuko Uenoyama
Atsuko Uenoyama