Title:
インデン誘導体、それらの製造および薬剤としての使用
Document Type and Number:
Japanese Patent JP2009514915
Kind Code:
A
Abstract:
The present invention makes reference to new indene derivatives with general formula (I), as well as to their preparation procedures, their application as medicament and the pharmaceutical compositions containing them. The new compounds of formula I show affinity for 5-HT 6 receptors and are, therefore, effective for treating diseases mediated by these receptors.
Inventors:
Jordi, Frigola-Constanza
Ramon, Mercedes-Vidal
Jörg, Holents
Maria, De, Las, Ermitus, Arcalde, Pais
Maria, De, Les, Neus, Mesquida, Estevez
Sarah, Lopez, Perez
Ramon, Mercedes-Vidal
Jörg, Holents
Maria, De, Las, Ermitus, Arcalde, Pais
Maria, De, Les, Neus, Mesquida, Estevez
Sarah, Lopez, Perez
Application Number:
JP2008539319A
Publication Date:
April 09, 2009
Filing Date:
November 07, 2006
Export Citation:
Assignee:
Laboratorios del Doctor Esteve Sociedad Anonima
International Classes:
C07C205/56; A61K31/165; A61K31/18; A61K31/192; A61K31/381; A61K31/40; A61K31/429; A61P1/04; A61P3/04; A61P3/10; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P35/00; A61P43/00; C07C201/12; C07C205/45; C07C209/36; C07C211/30; C07C211/60; C07C225/22; C07C303/38; C07C303/40; C07C309/85; C07C311/21; C07C311/44; C07D295/20; C07D333/62; C07D513/04
Domestic Patent References:
| JPH02141A | 1990-01-05 | |||
| JP2003523333A | 2003-08-05 | |||
| JP2002520404A | 2002-07-09 | |||
| JPS6160610A | 1986-03-28 | |||
| JPS5289669A | 1977-07-27 |
Foreign References:
| US5965619A | 1999-10-12 | |||
| GB1038725A | 1966-08-10 | |||
| US3622623A | 1971-11-23 | |||
| WO2005040212A2 | 2005-05-06 |
Other References:
JPN6012031030; Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｔｔｅｒｓ Ｖｏｌ．１４, 2004, ｐ．４５６９-４５７３
JPN6012031031; Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｅｔｅｒｓ Ｖｏｌ．１５, 2005, ｐ．１９８７-１９９１
JPN6012031026; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３４，Ｎｏ．３, 1991, ｐ．９１９-９２６
JPN6012031027; Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４１，Ｎｏ．２２, 1976, ｐ．３５４０-３５４５
JPN6012031028; Ｊｏｕｒｎａｌ ｆｕｒ ｐｒａｋｔｉｓｃｈｅ Ｃｈｅｍｉｅ Ｎ．Ｆ． Ｖｏｌ．１３９, 1934, ｐ．９４-９６
JPN6012031029; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３４, 1991, ｐ．１３８３-１３９４
JPN6012031031; Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｅｔｅｒｓ Ｖｏｌ．１５, 2005, ｐ．１９８７-１９９１
JPN6012031026; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３４，Ｎｏ．３, 1991, ｐ．９１９-９２６
JPN6012031027; Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４１，Ｎｏ．２２, 1976, ｐ．３５４０-３５４５
JPN6012031028; Ｊｏｕｒｎａｌ ｆｕｒ ｐｒａｋｔｉｓｃｈｅ Ｃｈｅｍｉｅ Ｎ．Ｆ． Ｖｏｌ．１３９, 1934, ｐ．９４-９６
JPN6012031029; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３４, 1991, ｐ．１３８３-１３９４
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota