Title:
INDENYL COMPOUND, PHARMACEUTICAL COMPOSITION AND MEDICAL USE THEREOF
Document Type and Number:
Japanese Patent JP2020079307
Kind Code:
A
Abstract:
To provide an indenyl compound, a pharmaceutical composition, and the medical use thereof.SOLUTION: Disclosed are a compound, for example, the compound of the formula (I) (where, R, R, Rto R, n, X, Y, Y' and E are described in the present specification), a pharmaceutical composition containing such a compound and a method of treating or preventing a disease or a state, for example, cancer. The compound is suitable for treating or preventing cancer, and the pharmaceutical composition including the compound and a carrier pharmacologically allowed is provided.SELECTED DRAWING: None
Inventors:
GARY A PIAZZA
CHEN SI
ADAM B KEETON
MICHAEL R BOYD
CHEN SI
ADAM B KEETON
MICHAEL R BOYD
Application Number:
JP2020029699A
Publication Date:
May 28, 2020
Filing Date:
February 25, 2020
Export Citation:
Assignee:
ADT PHARMACEUTICALS INC
International Classes:
C07C235/32; A61K31/16; A61K31/165; A61K31/167; A61K31/216; A61K31/265; A61K31/27; A61K31/341; A61K31/36; A61K31/40; A61K31/4025; A61K31/4178; A61K31/421; A61K31/422; A61K31/435; A61K31/4406; A61K31/4409; A61K31/443; A61K31/4439; A61K31/444; A61K31/445; A61K31/4525; A61K31/4545; A61K31/495; A61K31/496; A61K31/505; A61K31/506; A61K31/5375; A61K31/5377; A61K31/655; A61K31/661; A61K31/665; A61K31/675; A61K45/00; A61P35/00; A61P35/02; A61P35/04; A61P43/00; C07C237/20; C07D207/14; C07D207/335; C07D211/56; C07D211/58; C07D213/38; C07D213/40; C07D213/54; C07D213/75; C07D213/80; C07D239/42; C07D263/32; C07D295/185; C07D295/205; C07D307/52; C07D307/54; C07D401/12; C07D405/12; C07D407/12; C07D413/12
Domestic Patent References:
| JP2018505145A | 2018-02-22 | |||
| JP2017538772A | 2017-12-28 | |||
| JP2018501261A | 2018-01-18 | |||
| JP2007534702A | 2007-11-29 | |||
| JP2000514417A | 2000-10-31 | |||
| JP2009522364A | 2009-06-11 | |||
| JP2009514915A | 2009-04-09 | |||
| JP2002508358A | 2002-03-19 | |||
| JPH0687739A | 1994-03-29 | |||
| JPS50123651A | 1975-09-29 |
Foreign References:
| DE10163426A1 | 2003-07-03 |
Other References:
STELLA V.J., NTI-ADDAE K.W.: "Prodrug strategies to overcome poor water solubility", ADVANCED DRUG DELIVERY REVIEWS, vol. 59, JPN6021008430, 2007, pages 677 - 694, XP022211987, ISSN: 0004466231, DOI: 10.1016/j.addr.2007.05.013
LARSEN, C. S. ET AL., TEXTBOOK OF DRUG DESIGN AND DISCOVERY, vol. Charpter 14, JPN6014038866, 2002, pages 460 - 514, ISSN: 0004466227
BUNDGAARD H: "NOVEL CHEMICAL APPROACHES IN PRODRUG DESIGN", DRUGS OF THE FUTURE, vol. 16, no. 5, JPN5011002072, 1 May 1991 (1991-05-01), ES, pages 443 - 58, XP000196088, ISSN: 0004466228
周東智, 有機医薬分子論, vol. 2刷, JPN6017042086, 25 August 2012 (2012-08-25), pages 169 - 171, ISSN: 0004466229
製剤学・物理薬剤学, vol. 2版1刷, JPN6018001718, 2012, pages 259 - 66, ISSN: 0004466230
INT.J.CANCER, vol. 87, JPN6019032289, 2000, pages 155 - 164, ISSN: 0004466235
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, JPN6019035434, 2012, pages 17 - 29, ISSN: 0004466232
ANGEW. CHEM. INT. ED., vol. 43, JPN6019035436, 2004, pages 450 - 454, ISSN: 0004466233
MOL.CANCER THER., vol. 5, no. 1, JPN6019032287, 2006, pages 60 - 67, ISSN: 0004466234
LARSEN, C. S. ET AL., TEXTBOOK OF DRUG DESIGN AND DISCOVERY, vol. Charpter 14, JPN6014038866, 2002, pages 460 - 514, ISSN: 0004466227
BUNDGAARD H: "NOVEL CHEMICAL APPROACHES IN PRODRUG DESIGN", DRUGS OF THE FUTURE, vol. 16, no. 5, JPN5011002072, 1 May 1991 (1991-05-01), ES, pages 443 - 58, XP000196088, ISSN: 0004466228
周東智, 有機医薬分子論, vol. 2刷, JPN6017042086, 25 August 2012 (2012-08-25), pages 169 - 171, ISSN: 0004466229
製剤学・物理薬剤学, vol. 2版1刷, JPN6018001718, 2012, pages 259 - 66, ISSN: 0004466230
INT.J.CANCER, vol. 87, JPN6019032289, 2000, pages 155 - 164, ISSN: 0004466235
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, JPN6019035434, 2012, pages 17 - 29, ISSN: 0004466232
ANGEW. CHEM. INT. ED., vol. 43, JPN6019035436, 2004, pages 450 - 454, ISSN: 0004466233
MOL.CANCER THER., vol. 5, no. 1, JPN6019032287, 2006, pages 60 - 67, ISSN: 0004466234
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto