CNS障害の治療に有用なインドール誘導体

Japanese Patent JP2004501912

A

An indole derivative having the formula wherein a) Y<1 >is N, which is bound to Z, Z and Y<2 >are selected from CH2, CO, CS, SO and SO2; provided that at least one of Z and Y<2 >is CH2; Y<3>is O, S or CHR<7>and Y<4>is O, S or CHR<8>, provided that only one of Y<3 >and Y<4 >is O or S; b) Y<2 >is N, which is bound to Z, Z and Y<1 >are selected from CH2, CO, CS, SO and SO2; provided that at least one of Z and Y<1 >is CH2; Y<3>is CHR<7 >and Y<4>is O, S or CHR<8>; c) Y<2 >is N, which is bound to Z, Z and Y<3 >are selected from CH2, CO, CS, SO and SO2 provided that at least one of Z and Y<3 >is CH2; Y<1 >is CHR<6 >and Y<4 >is O, S or CHR<8>; W is a bond, O, S, CO, CS, SO or SO2; n is 0-5, m is 0-5 and n+m is 1-6; provided that when W is O or S, then n>=2 and m>=1; when W is CO, CS, SO or SO2, then n>=1 and m>=1; X is C, CH or N, provided that when X is C, the dotted line indicates a bond, and when X is N or CH, the dotted line indicates no bond; one of R<1>, R<2>, R<3 >and R<4 >forms a bond to X and the others of R<1>, R<2>, R<3>, R<4 >and R<5 >and R<9>-R<12 >are independently selected from hydrogen, halogen, cyano, nitro, amino, hydroxy, C1-6-alkyl-amino, di-( C1-6-alkyl )-amino, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6 alkoxy, C1-6-alkylthio, C1-6-alkyl substituted with hydroxy or thiol, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl, acyl, thioacyl, trifluoromethyl, trifluoromethylsulfonyl or C