To produce an indoleacetic acid compound, an intermediate thereof and a salt of the compound in a high yield by an industrial method.
The method of producing a compound useful as an aldose reductase inhibitor and represented by general formula (7) (wherein, R1, R2, R3 and R4 are mutually the same or different and denote each H, a 1-6C alkyl, a 1-6C alkyl replaced with an alkyl, a halogen, nitro, hydroxyl, a 1-6C alkoxyl or the like; and R7, R8, R9 and R10 are mutually the same or different and denote each H, a 1-6C alkyl, a halogen, nitro, hydroxyl, amino, carboxyl, cyano, a 1-6C alkoxyl, a 1-6C alkyl replaced with a halogen or the like) and the method for producing a compound which is an especially important intermediate and is represented by general formulae (4) or (5) which are further industrially performable methods are provided.
SHIOZAKI MAKOTO
NAKAGAWA YUICHI
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