Title:
【発明の名称】多重薬剤耐性細胞を抗腫瘍剤に対して感受性にするためのインドロカルバゾール誘導体
Document Type and Number:
Japanese Patent JPH10501527
Kind Code:
A
Abstract:
Staurosporin derivatives of formula (I), wherein R1 is an acyl radical having from 2 to 30 carbon atoms, an aliphatic hydrocarbon radical having up to 29 carbon atoms that is substituted by acyclic substituents, a cycloaliphatic or cycloaliphatic-aliphatic radical each having up to 29 carbon atoms, or a heterocyclic, heterocyclic-aliphatic or heteroaliphatic radical each having up to 20 carbon atoms and up to 9 hetero atoms, R2 is hydrogen, an aliphatic, carbocyclic or carbocyclic-aliphatic radical each having up to 29 carbon atoms, a heterocyclic or heterocyclic-aliphatic radical each having up to 20 carbon atoms and up to 9 hetero atoms, or an acyl radical having up to 30 carbon atoms, and R3 is hydrogen, hydroxy, lower alkoxy or oxo, with the exception of the compound of formula (I) wherein R1 is methoxycarbonylmethyl, R2 is benzoyl and R3 is hydrogen, are described. These compounds can be used for avoiding or removing multi-drug resistance to anti-tumour agents.
Inventors:
Regus, Urs
Caravatti, Giorgio
Fredenhagen, Andreas
Buccal, oscar
Caravatti, Giorgio
Fredenhagen, Andreas
Buccal, oscar
Application Number:
JP50024596A
Publication Date:
February 10, 1998
Filing Date:
May 19, 1995
Export Citation:
Assignee:
Ciba-Geigy Akchen Gezel Shaft
International Classes:
A61K31/55; A61P35/00; C07D498/22; C07H9/06; C07H19/044; (IPC1-7): C07D498/22; A61K31/55
Attorney, Agent or Firm:
Takashi Ishida (3 others)