Title:
誘導可能な局所接着キナーゼ細胞アッセイ
Document Type and Number:
Japanese Patent JP2006500022
Kind Code:
A
Abstract:
The cell-based assay of the present invention exploits the biology of FAK in conjunction an inducible gene expression system to exogenously control FAK expression and FAK phosphorylation at the tyrosine residue at position 397 (Y<397>). The cell-based assay of the present invention is flexible and can measure FAK phosphorylation at Y397, total FAK phosphorylation, identify mutant FAK proteins and measure a combination of protein and phosphotyrosine.
Inventors:
Roberts, Walter Gregory
Whalen, Pamela Matthews
Ang, Ethan James Techre
Whalen, Pamela Matthews
Ang, Ethan James Techre
Application Number:
JP2004537413A
Publication Date:
January 05, 2006
Filing Date:
September 08, 2003
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
C12Q1/48; C12Q1/68; C12N1/21; C12N5/10; C12N9/12; C12N15/09; C12Q1/02; G01N33/15; G01N33/50; G01N33/53; G01N33/573
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho