ＲＮＡでの幹細胞分化による膵臓β細胞の誘導 - Aryl Biotechnology and Pharmaceuticals, Incorporated

Title:

ＲＮＡでの幹細胞分化による膵臓β細胞の誘導

Document Type and Number:

Japanese Patent JP7125394

Kind Code:

B2

Abstract:

A novel method of inducing or producing pancreatic beta cells from human induced pluripotent stem cells at an unprecedented efficiency and functionality. The core of the invention is the use of experimentally discovered mRNAs at multiple critical differentiation decision points along a pluripotent to mesendoderm to endoderm to pancreatic endocrine cells to pancreatic beta cells pathway in a previously unknown manner.

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Inventors:

Wang Zi Wu
Nee, Yuhui
Zhao, Yuanyuan

Application Number:

JP2019525968A

Publication Date:

August 24, 2022

Filing Date:

November 16, 2017

Export Citation:

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Assignee:

Aryl Biotechnology and Pharmaceuticals, Incorporated

International Classes:

C12N5/10; A61K35/39; A61L27/38; A61P3/10

Foreign References:

US20120207744
WO2015178397A1
WO2016134313A1

Other References:

Clin Exp Med,2015年,Vol.15,P.501-509
Differentiation,2014年,Vol.87,P.200-208
STEM CELLS TRANSLATIONAL MEDICINE,2016年,Vol.5,P.1525-1537

Attorney, Agent or Firm:

Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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