Title:
【発明の名称】置換フェンアルキル化合物によるマトリックスプロテアーゼの阻害
Document Type and Number:
Japanese Patent JP3305328
Kind Code:
B2
Abstract:
Matrix metalloprotease inhibiting compounds, pharmaceutical compositions thereof and a method of disease treatment using such compounds are presented. The compounds of the invention have generalized formula (I), wherein R<25> is a substituted phenylethyl moiety. These compounds are useful for inhibiting matrix metalloproteases and, therefore, combatting conditions to which MMP's contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal disease, corneal ulceration, proteinuria, aneurysmal aortic disease, dystrophobic epidermolysis, bullosa, conditions leading to inflammatory responses, osteopenias mediated by MMP activity, tempero mandibular joint disease, demyelating diseases of the nervous system, tumor metastasis or degenerative cartilage loss following traumatic joint injury, and coronary thrombosis from athrosclerotic plaque rupture. The present invention also provides pharmaceutical compositions and methods for treating such conditions.
Inventors:
Donald Jay Wollanine
Application Number:
JP54097997A
Publication Date:
July 22, 2002
Filing Date:
May 12, 1997
Export Citation:
Assignee:
Bayer Corporation
International Classes:
A61K31/166; A61K31/19; A61K31/195; A61K31/215; A61K31/216; A61K31/445; A61K31/535; A61K31/5375; A61P1/02; A61P9/10; A61P27/02; A61P29/00; A61P43/00; C07D295/12; C07C17/16; C07C45/46; C07C59/88; C07C69/738; C07C235/84; C07D295/18; C07D295/192; (IPC1-7): C07C235/84; A61K31/166; A61K31/195; A61K31/216; A61K31/445; A61K31/5375; A61P1/02; A61P9/10; A61P27/02; A61P29/00; A61P43/00; C07D295/12; C07D295/18
Domestic Patent References:
| JP10509146A | ||||
| JP2001509783A |
Attorney, Agent or Firm:
Toshio Yano (2 outside)