Title:
Inhibitor of the Breton tyrosine kinase
Document Type and Number:
Japanese Patent JP6118453
Kind Code:
B2
Abstract:
This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
Inventors:
Chin, Elbert
Weikart, Robert James
Yun, Waya
Chang, Jin
Weikart, Robert James
Yun, Waya
Chang, Jin
Application Number:
JP2016505779A
Publication Date:
April 19, 2017
Filing Date:
March 31, 2014
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D471/04; A61K31/437; A61K31/444; A61K31/4545; A61K45/00; A61P3/10; A61P9/00; A61P11/06; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00
Domestic Patent References:
| JP2007531760A | ||||
| JP2010526768A | ||||
| JP2002512216A | ||||
| JP2011530518A |
Foreign References:
| EP1749829A1 |
Attorney, Agent or Firm:
Patent business corporation Tsukuni
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