Title:
Α−アミノ−Β−カルボキシムコン酸セミアルデヒドデカルボキシラーゼの阻害剤
Document Type and Number:
Japanese Patent JP2020500838
Kind Code:
A
Abstract:
本開示は、ＮＡＤ＋生合成における異常と関連した疾患および障害、例えば、代謝障害、神経変性疾患、慢性炎症疾患、肝疾患、および老化と関連した疾患の予防および／または治療に有用である、α−アミノ−β−カルボキシムコン酸セミアルデヒドデカルボキシラーゼ（ＡＣＭＳＤ）の活性を調節することができる化合物を開示する。本出願は、その化合物を含む薬学的組成物およびこのような化合物の薬剤としての使用も開示する。
Inventors:
Roberto Perricchiari
Application Number:
JP2019520068A
Publication Date:
January 16, 2020
Filing Date:
October 13, 2017
Export Citation:
Assignee:
Thiesse Pharma Sochieta Responsabilita Limitata
International Classes:
C07D239/52; A61K31/513; A61K31/662; A61K45/00; A61P1/16; A61P29/00; A61P31/04; A61P31/12; A61P37/06; A61P43/00; C07D239/545; C07D239/56; C07D401/06; C07D403/12; C07D417/12; C07F9/6512
Domestic Patent References:
| JP2004203748A | 2004-07-22 | |||
| JP2010532350A | 2010-10-07 |
Foreign References:
| WO2012135641A2 | 2012-10-04 | |||
| WO2012061415A1 | 2012-05-10 | |||
| CN102295608A | 2011-12-28 | |||
| US3637684A | 1972-01-25 | |||
| US5736550A | 1998-04-07 | |||
| US20130317029A1 | 2013-11-28 | |||
| US20060100226A1 | 2006-05-11 |
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Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Kazumi Nakamura
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Kazumi Nakamura