INHIBITOR OF BACTERIAL BIOFILM FORMATION

Title:

INHIBITOR OF BACTERIAL BIOFILM FORMATION

Document Type and Number:

Japanese Patent JP3631510

Kind Code:

B2

Abstract:

PURPOSE: To obtain the subject inhibitor, capable of inhibiting a key enzyme guanosine diphospho-D-mannonse dehydrogenase for biosynthesis of alginates by Pseudomonas aeruginosa and useful as a therapeutic agent for intractable infectious diseases, especially diffuse panbronchiolitis due to the Pseudomonas aeruginosa.
CONSTITUTION: This inhibitor of bacterial biofilm formation contains a compound expressed by formula I (R1 is H, a 1-5C alkyl or an aglycone part of a 12- to a 16-membered ring macrolide; R2 is H or hydroxyl group) or its pharmacologically permissible salts as an active ingredient. 9- Dehydrodemycarosylplatenomycin, etc., in which R1 is the group expressed by formula II and R2 is hydroxyl group are cited as the compound expressed by formula I. The 9-dehydrodemycarosylplatenomycin can be prepared by cleaving mycarose obtained by acylating mydecamycin A3 which is a 16-membered ring macrolide. Furthermore, the dose of the compound expressed by formula I for an adult is about 0.01-30mg/kg, preferably 0.1-10mg/kg.

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Inventors:

Hiroyuki Kobayashi
Araaki Minako
Osamu Hara
Seiji Shibahara

Application Number:

JP11236394A

Publication Date:

March 23, 2005

Filing Date:

May 26, 1994

Export Citation:

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Assignee:

Meiji Seika Co., Ltd.

International Classes:

C07H5/06; A61K31/70; A61K31/7008; A61K31/7042; A61K31/7048; A61P31/04; C07H17/08; (IPC1-7): A61K31/70; A61P31/04; C07H5/06; C07H17/08

Foreign References:

WO1993018048A1

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