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Title:
銅含有アミン・オキシダーゼの阻害剤
Document Type and Number:
Japanese Patent JP2004502682
Kind Code:
A
Abstract:
The present invention is directed to hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The compounds have the general formula:or a pharmaceutically acceptable solvate, hydrate, or salt thereof, wherein R<1 >to R<8 >and X are as defined herein.

Inventors:
Smith, david john
Yarkanen, Maluk
Furep, Ferenc
Lazar, Larslaw
Sakonui, Salt
Bernards, Garbol
Application Number:
JP2002507795A
Publication Date:
January 29, 2004
Filing Date:
July 04, 2001
Export Citation:
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Assignee:
BIOTY THERAPIES CORPORATION
International Classes:
A61K31/00; A61K31/131; A61K31/14; A61K31/15; A61K31/40; A61K31/445; A61K31/472; A61K31/5395; A61P1/04; A61P1/16; A61P3/00; A61P3/10; A61P9/00; A61P9/10; A61P11/06; A61P17/00; A61P19/02; A61P25/00; C07D217/16; A61P29/00; A61P37/00; A61P43/00; C07B61/00; C07D273/04; C07D498/04; C07D498/10; (IPC1-7): C07D273/04; A61K31/5395; A61P1/04; A61P1/16; A61P3/10; A61P9/00; A61P9/10; A61P11/06; A61P17/00; A61P19/02; A61P25/00; A61P29/00; A61P37/00; A61P43/00; C07D498/04; C07D498/10
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Kazuhiro Nakamura
Masaya Nishiyama
Higuchi Souji