Title:
INHIBITOR OF ENDOPLASMIC RETICULUM STRESS IN CARDIAC MUSCLE
Document Type and Number:
Japanese Patent JP2009078977
Kind Code:
A
Abstract:
To provide an inhibitor of endoplasmic reticulum stress in cardiac muscle, which prevents and/or treats heart failure induced by endoplasmic reticulum stress by effectively suppressing cell death of cardiac muscle and lowering of cardiac functions by suppressing endoplasmic reticulum stress.
The inhibitor of endoplasmic reticulum stress in cardiac muscle comprises sodium 4-phenylbutyrate as an effective ingredient, and is parenterally administered in an amount of 4-12.5 mg in terms of sodium 4-phenylbutyrate per kg body weight per day.
Inventors:
MINAMINO TETSUO
HORI SHOJI
KITAKAZE MASAFUMI
TOMI KAIEI
HORI SHOJI
KITAKAZE MASAFUMI
TOMI KAIEI
Application Number:
JP2007247227A
Publication Date:
April 16, 2009
Filing Date:
September 25, 2007
Export Citation:
Assignee:
JAPAN HEALTH SCIENCE FOUND
UNIV OSAKA
UNIV OSAKA
International Classes:
A61K31/192; A61P9/04; C12N15/09
Domestic Patent References:
| JPH09506079A | 1997-06-17 | |||
| JP2007504131A | 2007-03-01 | |||
| JP2009530398A | 2009-08-27 |
Foreign References:
| WO2006031931A2 | 2006-03-23 |
Other References:
JPN6013007506; ＮＩＩＮＵＭＡ，Ｙ． ｅｔ ａｌ: '４-ｐｈｅｎｙｌｂｕｔｙｒａｔｅ ｐｒｏｔｅｃｔｓ ａｇａｉｎｓｔ ＥＲ ｓｔｒｅｓｓ-ｉｎｄｕｃｅｄ ｃｅｌｌ ｄｅａｔｈ ｂｙ ｒｅｄｕｃｉｎｇ ｕｎｆｏｌｄｅｄ ｐｒｏｔｅｉｎｓ ｉｎ ｔｈｅ' Ｊ Ｐｈａｒｍａｃｏｌ Ｓｃｉ Ｖｏｌ．９１， Ｓｕｐｐｌｅｍｅｎｔ, 2003, ｐ．８１Ｐ
JPN6013007508; ＪＡＮＧ，Ｙ．Ｍ． ｅｔ ａｌ: ＦＥＢＳ ｌｅｔｔｅｒｓ Ｖｏｌ．５７７， Ｎｏ．３, 2004, ｐ．４８３-９０
JPN6013007510; 窪田杏子 他: '４-ｐｈｅｎｙｌｂｕｔｙｒａｔｅの小胞体ストレス抑制作用とＰａｅｌ受容体折りたたみ促進効果' 日本薬理学雑誌 Ｖｏｌ．１２３， Ｎｏ．１, 2004, ｐ．１２Ｐ
JPN6013007512; 鈴木智弓 他: 'Ｄｏｘｏｒｕｂｉｃｉｎ誘発性心毒性に関する研究-ＥＲストレス経路の関与-' 日本医療薬学会年会講演要旨集 １６ｔｈ, 2006, ｐ．３３５
JPN6013007515; 鈴木智弓 他: 'Ｄｏｘｏｒｕｂｉｃｉｎ誘発性心毒性に関する研究-Ｃａｓｐａｓｅ-１２と［Ｃａ２＋］ｉの関与-' 日本薬学会年会要旨集 １２７ｔｈ， Ｎｏ．２, 200703, ｐ．１４９
JPN6013007504; ＯＫＡＪＩＭＡ，Ｍ． ｅｔ ａｌ: 'Ｔｈｅ Ｒｅｄｕｃｔｉｏｎ ｏｆ Ｃｅｌｌｕｌａｒ ＥＲ Ｓｔｒｅｓｓ Ｒｅｇａｒｄｉｎｇ ｗｉｔｈ Ｃｈｅｍｉｃａｌ Ｃｈａｐｅｒｏｎ Ｉｍｐｒｏｖｅｓ Ｍｙｏｃａｒｄｉａｌ Ｉｓｃｈｅｍｉａ Ｒｅ' Ｃｉｒｃ Ｊ Ｖｏｌ．７１， Ｓｕｐｐｌｅｍｅｎｔ, 2007, ｐ．５３６
JPN6013007508; ＪＡＮＧ，Ｙ．Ｍ． ｅｔ ａｌ: ＦＥＢＳ ｌｅｔｔｅｒｓ Ｖｏｌ．５７７， Ｎｏ．３, 2004, ｐ．４８３-９０
JPN6013007510; 窪田杏子 他: '４-ｐｈｅｎｙｌｂｕｔｙｒａｔｅの小胞体ストレス抑制作用とＰａｅｌ受容体折りたたみ促進効果' 日本薬理学雑誌 Ｖｏｌ．１２３， Ｎｏ．１, 2004, ｐ．１２Ｐ
JPN6013007512; 鈴木智弓 他: 'Ｄｏｘｏｒｕｂｉｃｉｎ誘発性心毒性に関する研究-ＥＲストレス経路の関与-' 日本医療薬学会年会講演要旨集 １６ｔｈ, 2006, ｐ．３３５
JPN6013007515; 鈴木智弓 他: 'Ｄｏｘｏｒｕｂｉｃｉｎ誘発性心毒性に関する研究-Ｃａｓｐａｓｅ-１２と［Ｃａ２＋］ｉの関与-' 日本薬学会年会要旨集 １２７ｔｈ， Ｎｏ．２, 200703, ｐ．１４９
JPN6013007504; ＯＫＡＪＩＭＡ，Ｍ． ｅｔ ａｌ: 'Ｔｈｅ Ｒｅｄｕｃｔｉｏｎ ｏｆ Ｃｅｌｌｕｌａｒ ＥＲ Ｓｔｒｅｓｓ Ｒｅｇａｒｄｉｎｇ ｗｉｔｈ Ｃｈｅｍｉｃａｌ Ｃｈａｐｅｒｏｎ Ｉｍｐｒｏｖｅｓ Ｍｙｏｃａｒｄｉａｌ Ｉｓｃｈｅｍｉａ Ｒｅ' Ｃｉｒｃ Ｊ Ｖｏｌ．７１， Ｓｕｐｐｌｅｍｅｎｔ, 2007, ｐ．５３６
Attorney, Agent or Firm:
Ryu Iwatani