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Title:
INHIBITOR OF FARNESYL PROTEIN TRANSFERASE
Document Type and Number:
Japanese Patent JPH05294890
Kind Code:
A
Abstract:

PURPOSE: To obtain the subject compounds each of which is capable of inhibiting a farnesyl protein transferase and preventing farnesylation of an oncogene protein Ras.

CONSTITUTION: The inhibitors are compounds represented by formula I (wherein: each of R1 and R2 is H, a 1-5C alkyl or phenyl group or a 1-5C alkyl group substituted with methyl group(s), or the like) or their medically-acceptable salts, such as a compound represented by formula II. Such a compound represented by formula I is prepared, for example, by culturing fungi of the Chaetomella acutiseta MF5685 (ATCC74113) in an aqueous nutrient medium contg. an anabolizable carbon source (such as D-glucose or glyceol) and nitrogen source (such as glycine or methionine), preferably under aerobic conditions. The therapeutically-effective daily dosage of the compounds represented by formula I is 0.1 to 20 mg/kg, or preferably, 0.5 to 10 mg/kg.


Inventors:
SHIEO BUTSUKUSU SHINGU
JIERARUDO EFU BIRUZU
RATSUSERU BII RINGAMU
KIISU SHII SHIRUBAAMAN
DEBORA ERU JINKU
Application Number:
JP32964192A
Publication Date:
November 09, 1993
Filing Date:
December 09, 1992
Export Citation:
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Assignee:
MERCK & CO INC
International Classes:
A61K31/19; A61K31/23; A61P35/00; A61P43/00; C07C57/13; C07C57/155; C07C69/347; C07C69/602; C12N9/99; C12P7/26; C12P7/44; C12P17/04; C12R1/01; (IPC1-7): C07C57/155; A61K31/19; A61K31/23; C07C69/347; C12P7/26; C12P17/04
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)



 
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