PURPOSE: To obtain the subject compounds each of which is capable of inhibiting a farnesyl protein transferase and preventing farnesylation of an oncogene protein Ras.
CONSTITUTION: The inhibitors are compounds represented by formula I (wherein: each of R1 and R2 is H, a 1-5C alkyl or phenyl group or a 1-5C alkyl group substituted with methyl group(s), or the like) or their medically-acceptable salts, such as a compound represented by formula II. Such a compound represented by formula I is prepared, for example, by culturing fungi of the Chaetomella acutiseta MF5685 (ATCC74113) in an aqueous nutrient medium contg. an anabolizable carbon source (such as D-glucose or glyceol) and nitrogen source (such as glycine or methionine), preferably under aerobic conditions. The therapeutically-effective daily dosage of the compounds represented by formula I is 0.1 to 20 mg/kg, or preferably, 0.5 to 10 mg/kg.
JIERARUDO EFU BIRUZU
RATSUSERU BII RINGAMU
KIISU SHII SHIRUBAAMAN
DEBORA ERU JINKU