INHIBITOR OF HYALURONIDASE

Japanese Patent JP3807782

B2

PROBLEM TO BE SOLVED: To obtain an inhibitor of hyaluronidases, having excellent inhibiting activities against hyaluronidases and excellent in safety.
SOLUTION: This inhibitor of hyaluronidases comprises an extract of a seaweed belonging to the genera Monostroma, Ulva, Enteromorpha, Bryopsis, Caulerpa and Codium which are green algae, the genera Analipus, Cladosiphon, Nemacystis, Ecklonia, Lessonia, Macrocystis, Fucus, Ascophyllum and Durvillea which are brown algae, the genera Porphyra, Gelidium, Beckerella, Pterocladia, Gloiopeltis, Eucheuma, Gigartina, Iridaea, Chondrus, Rhodymenia and Ceramium which are red algae as an active ingredient. Thereby, an active substance contained in the extract and inhibiting the hyaluronidases has suppressing actions on the decomposition of hyaluronic acid, is thereby capable of activating dermal cells and preventing the skin from aging and manifests excellent effects on the prevention of the occurrence of wrinkles and skin roughening and the impartment of the smooth, moist and fresh skin. The extract is blended in a dermal preparation for external use to thereby provide the inhibitor of hyaluronidases suitable as the dermal preparation for external use, etc., having high safety. The inhibitor maintains wettability of joints, is useful as even an therapeutic agent, etc., for the joints and further as an antiinflammatory and an antiallergic agent and can be used for various applications such as medicines, quasi-drugs, cosmetics, etc.

Shinya Ebata
Yahiro Hirota
Tsuneo Miyahara

JP15446896A

August 09, 2006

June 14, 1996

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LION Corporation

A61K8/00; A61K8/97; A61K8/96; A61K36/02; A61P17/00; A61P17/16; A61P43/00; A61Q19/00; A61Q19/08; (IPC1-7): A61K35/80; A61K7/00; A61K7/00; A61K7/48

JP7101871A
JP6009422A

Eisuke Fujimoto
Masayoshi Kanda

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