Title:
ＥＧＦＲの阻害剤およびその使用法
Document Type and Number:
Japanese Patent JP7335275
Kind Code:
B2
Abstract:
The application relates to a compound having Formula Ia or Ib: or a pharmaceutically acceptable salt, hydrate, or solvate thereof, which modulates the activity of EGFR, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which EGFR plays a role.
Inventors:
Nathaniel S. Gray
Doris de Clerc
Jebon Jean
Pasi Jeanne
Cilic To
Michael Ek
Eunyoung Park
David Hepner
Doris de Clerc
Jebon Jean
Pasi Jeanne
Cilic To
Michael Ek
Eunyoung Park
David Hepner
Application Number:
JP2020566547A
Publication Date:
August 29, 2023
Filing Date:
February 20, 2019
Export Citation:
Assignee:
Dana Farber Cancer Institute, Incorporated
International Classes:
C07D243/38; A61K31/551; A61K45/00; A61P35/00; A61P43/00; C07D401/06; C07D401/10; C07D401/14; C07D403/04; C07D403/06; C07D403/10; C07D403/14; C07D417/06; C07D417/14; C07D471/04
Domestic Patent References:
| JP2015205911A | ||||
| JP2012511054A | ||||
| JP2021514400A |
Foreign References:
| WO2015196072A2 | ||||
| WO2017177092A1 | ||||
| WO2014160430A1 | ||||
| US20070105835 | ||||
| WO2016201370A1 | ||||
| WO2009124399A1 |
Other References:
Praveen Kumar, Chintakunta et al.,Synthesis and biological evaluation of 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one structural derivatives as anti-cancer and apoptosis inducing agents,European Journal of Medicinal Chemistry,(2016), 108, 674-686,2016年
Mastalerz, Harold et al.,Novel C-5 aminomethyl pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases,Bioorganic & Medicinal Chemistry Letters,2007年,(2007), 17(10), 2828-2833
Mastalerz, Harold et al.,Novel C-5 aminomethyl pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases,Bioorganic & Medicinal Chemistry Letters,2007年,(2007), 17(10), 2828-2833
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mihiro
Tatsuhiko Abe
Shinya Mihiro
Tatsuhiko Abe
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