Title:
INHIBITORS OF E1 ACTIVATING ENZYMES
Document Type and Number:
Japanese Patent JP2020055841
Kind Code:
A
Abstract:
To provide inhibitors of E1 activating enzymes.SOLUTION: This invention relates to compounds of the formula (I) that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders including cancers and inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia. The compounds are useful for inhibiting E1 activity in vitro and in vivo, and are useful for treating cell proliferation disorders, particularly cancers, and other disorders associated with E1 activity.SELECTED DRAWING: None
Inventors:
STEVEN P LANGSTON
OLHAVA EDWARD J
VYSKOCIL STEPAN
OLHAVA EDWARD J
VYSKOCIL STEPAN
Application Number:
JP2019219430A
Publication Date:
April 09, 2020
Filing Date:
December 04, 2019
Export Citation:
Assignee:
MILLENNIUM PHARM INC
International Classes:
C07D303/06; A61K31/519; A61K31/7064; A61K31/7076; A61P9/00; A61P35/00; A61P35/02; A61P37/02; A61P43/00; C07C33/12; C07D303/14; C07D487/04; C07D493/04; C07F7/08; C07F7/10; C07H19/14; C07H19/173
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto