INHIBITORS OF HISTONE DEACETYLASE

Title:

INHIBITORS OF HISTONE DEACETYLASE

Document Type and Number:

Japanese Patent JP2015145401

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide compounds for medicament to inhibit histone deacetylase.SOLUTION: This invention provides a compound such as phenyl hydroxamic acid substituted with a group comprising, for example, oxazepine, diazepine, thiazepine skeletons, pyrimidine-5-yl hydroxamic acid substituted with a group comprising a diazabicyclo ring, or alkyl or alkenyl hydroxamic acid substituted with a group comprising an azepine skeleton.

Inventors:

ROBERT DEZIEL
LEIT SILVANA
PATRICK BEAULIEU
YVES ANDRE CHANTIGNY
JOHN MANCUSO
TESSIER PIERRE
GIDEON SHAPIRO
RICHARD CHESWORTH
DAVID SMIL

Application Number:

JP2015075545A

Publication Date:

August 13, 2015

Filing Date:

April 02, 2015

Export Citation:

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Assignee:

METHYLGENE INC
FORM PHARMACEUTICALS INC

International Classes:

C07C259/10; C07C259/06; C07D209/08; C07D209/52; C07D209/94; C07D213/78; C07D221/12; C07D223/22; C07D223/26; C07D239/42; C07D243/24; C07D243/38; C07D267/20; C07D279/22; C07D281/16; C07D291/08; C07D313/14; C07D401/14; C07D403/04; C07D403/14; C07D413/04; C07D413/06; C07D413/12; C07D471/08; C07D487/04; C07D487/08; C07D487/16; C07D491/08; C07D495/04; C07D498/04; C07D513/04

Domestic Patent References:

JP5727649B2	2015-06-03
JP5583406B2	2014-09-03
JP2005526763A	2005-09-08
JP2005503341A	2005-02-03
JPS5643283A	1981-04-21

Foreign References:

WO2006097449A1	2006-09-21
WO2006088949A1	2006-08-24

Other References:

JPN5009020314; ＭＩＬＬＥＲ　Ｔ　Ａ: ＥＸＰＥＲＴ　ＯＰＩＮＩＯＮ　ＯＮ　ＴＨＥＲＡＰＥＵＴＩＣ　ＰＡＴＥＮＴＳＶ１４　Ｎ６, 20040101, Ｐ７９１-８０４, ＡＳＨＬＥＹ　ＰＵＢＬＩＣＡＴＩＯＮＳ

Attorney, Agent or Firm:

Asamura patent office

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