Title:
阻害剤およびその使用法
Document Type and Number:
Japanese Patent JP2006515859
Kind Code:
A
Abstract:
New triterpenoid derivatives with various substituents at the C-17 position of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) were synthesized. Among them, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile (CNDDO), 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole, 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl)-2-methylimidazole, 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl)-4-methylimidazole show extremely high inhibitory activity (IC50=0.01-1 pM level) against production of nitric oxide induced by interferon-gamma in mouse macrophages. These compounds can be used in the prevention or treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, multiple sclerosis, rheumatoid arthritis, and other inflammatory diseases. All the new triterpenoid derivatives are more potent than previously known CDDO.
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Inventors:
Honda Tadashi
Honda Sachiko
Gribble Gordon W.
Spawn Michael Bee.
Sue Nanjo
Honda Sachiko
Gribble Gordon W.
Spawn Michael Bee.
Sue Nanjo
Application Number:
JP2004566891A
Publication Date:
June 08, 2006
Filing Date:
May 12, 2003
Export Citation:
Assignee:
Trustees of Dartmouth College
International Classes:
C07J63/00; A61K31/275; A61K31/4172; A61K31/4184; A61K31/4196; A61K31/56; A61K31/704; A61K45/00; A61P1/00; A61P1/04; A61P1/16; A61P1/18; A61P7/00; A61P11/00; A61P13/08; A61P13/12; A61P15/00; A61P17/00; A61P19/00; A61P19/02; A61P21/00; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P35/00; A61P37/02; A61P43/00; C07D233/54; C07D233/60; C07D233/68; C07D235/06; C07D249/08; C07D249/10; C07D317/34; C07H15/24
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Koichi Niimi
Kazunori Hashimoto
Koichi Niimi