Title:
INJECTABLE HYDROGEL, METHOD FOR PREPARING HYDROGEL, HYDROGEL PREPARATION KIT, AND USE OF HYDROGEL AND METHOD THEREOF
Document Type and Number:
Japanese Patent JP2014177460
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a quickly preparable and low-risk method for preparing hydrogel comprising an injectable thiol group, and to provide a hydrogel preparation kit, and to provide a use of hydrogel and a method thereof.SOLUTION: Hydrogel is prepared by binding (a) a water soluble polymer containing a thiol group to (b) a water soluble metal salt in an aqueous solution. Hydrogel can be prepared quickly to be used as blood vessel sealant, a vessel closing device or a drug delivery carrier. Preferably, AuClis used as a metal salt. As a water soluble polymer, Polysaccharide, gelatin, cellulose, starch, lipid, albumin, collagen, polylysine, or the like is used. The water soluble polymer comprises polyethylene glycol comprising at least four branches. The hydrogel is biodegradable and is prepared in less than about 60 seconds.
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Inventors:
LISA MELLIN
NIKLAS BORG
MARTINA KAELLROT JANSTAL
NIKLAS BORG
MARTINA KAELLROT JANSTAL
Application Number:
JP2014046747A
Publication Date:
September 25, 2014
Filing Date:
March 10, 2014
Export Citation:
Assignee:
ST JUDE MEDICAL SYSTEMS AB
International Classes:
A61K47/02; A61K9/06; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/42; A61L31/00; A61P9/00
Domestic Patent References:
| JPH10158195A | 1998-06-16 | |||
| JP2011173887A | 2011-09-08 |
Foreign References:
| EP2597110A1 | 2013-05-29 | |||
| WO2012035598A1 | 2012-03-22 | |||
| WO2010087912A1 | 2010-08-05 |
Other References:
JPN6015008124; Ｉｂｏｎ Ｏｄｒｉｏｚｏｌａ ｅｔ ａｌ: Ｏｒｇａｎｉｃ ＆ Ｂｉｏｍｏｌｅｃｕｌａｒ Ｃｈｅｍｉｓｔｒｙ ｖｏｌ．９， ｎｏ．１４, 2011, ｐ．５０５９-５０６１
Attorney, Agent or Firm:
Tadao Hirata
Kenji Tsunoda
Yuji Iwanaga
Keiko Nakamura
Endo Wako
Takashi Nomiyama
Hiroyuki Ito
Kenji Tsunoda
Yuji Iwanaga
Keiko Nakamura
Endo Wako
Takashi Nomiyama
Hiroyuki Ito