Injectable silk fibroin particles and their use

Japanese Patent JP6362540

B2

The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein are injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection) and/or be molded flexibly into a tissue void of any shape and/or size. In some embodiments, the composition described herein comprises a plurality of silk fibroin particles, which can retain their original volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.

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Bella's Evangelia
Marla Casey
Rubin Jay Peter
Kaplan David L.
Yo James Jay.

JP2014541327A

July 25, 2018

November 09, 2012

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TRUSTEES OF TUFTS COLLEGE

A61L27/22; A61L27/16; A61L27/18; A61L27/20; A61L27/24; A61L27/38; A61L27/54; A61L27/56; A61L27/58; A61L27/60

WO2010123945A1

J Biomed Mater Res A,2011年10月,Vol.99, No.1,p.16-28
南山堂 医学大辞典(豪華版),1998年,p.1366, 「注射剤」の項

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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