Title:
インテグリン受容体拮抗薬
Document Type and Number:
Japanese Patent JP3589633
Kind Code:
B2
Abstract:
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alpha v beta 3, alpha v beta 5 and/or alpha v beta 6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, and tumor growth and metastasis.
Inventors:
Mark Gun, Dagan
Robert Es Meissner
Hatsuchinson, Jiyoung H
Halchienko, Wadir
Askie You, Ben See
Coleman, Paul Jay
Pattern, Michael A.
One, Chiabin
Perkins, James Aye
Robert Es Meissner
Hatsuchinson, Jiyoung H
Halchienko, Wadir
Askie You, Ben See
Coleman, Paul Jay
Pattern, Michael A.
One, Chiabin
Perkins, James Aye
Application Number:
JP2000539023A
Publication Date:
November 17, 2004
Filing Date:
December 14, 1998
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
A61K31/415; A61K31/4375; A61K31/44; A61K31/4427; A61K31/4439; A61K31/444; A61K31/4709; A61K31/538; A61K31/5383; A61K31/66; A61K31/663; A61K45/00; A61K45/06; A61P3/14; A61P9/00; A61P9/10; A61P17/02; A61P19/08; A61P19/10; A61P27/02; A61P29/00; C07D401/06; A61P31/12; A61P35/00; A61P43/00; C07D401/14; C07D471/04; C07D519/00; C07D; (IPC1-7): C07D471/04; A61K31/4375; A61K31/4439; A61K31/444; A61K31/4709; A61K31/538; A61K31/5383; A61P3/14; A61P9/00; A61P9/10; A61P17/02; A61P19/10; A61P27/02; A61P29/00; A61P31/12; A61P35/00; A61P43/00; C07D401/06; C07D401/14; C07D519/00
Domestic Patent References:
| JP6009525A | ||||
| JP51143696A | ||||
| JP49095980A | ||||
| JP10291988A |
Foreign References:
| WO1997014417A1 | ||||
| WO1998054168A1 |
Other References:
Eur.J.Med.Chem.,(1992),27(8),p.779-89
Chemische Berichte,(1975),108(1),p.372-4
Chemische Berichte,(1975),108(1),p.372-4
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Akio Ichiiri
Makoto Ono
Katsuma Osaki