Title:
血清サンプル中の抗薬物抗体を検出するための干渉抑制イムノアッセイ
Document Type and Number:
Japanese Patent JP6761085
Kind Code:
B2
Abstract:
Herein is reported an enzyme linked immunosorbent assay for the detection of anti-drug antibodies against a drug antibody in a sample comprising a capture drug antibody and a tracer drug antibody, wherein the capture drug antibody and the tracer drug antibody are employed in a concentration of 0.5 μg/ml or more, the sample is incubated simultaneously with the capture drug antibody and the tracer drug antibody for 1 to 24 hours, the capture drug antibody and the tracer drug antibody are derivatized via a single lysine residue, the sample comprises 10% serum, and oligomeric human IgG is added to the sample prior to the incubation with the capture drug antibody and the tracer drug antibody.
Inventors:
Stuben Lauho, Kai-Gunner
Vogel, Rudolf
Vogel, Rudolf
Application Number:
JP2019137030A
Publication Date:
September 23, 2020
Filing Date:
July 25, 2019
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
G01N33/53; A61K39/395; A61P19/02; A61P29/00; A61P35/00; G01N33/543
Domestic Patent References:
| JP2011506943A |
Foreign References:
| WO2012064627A2 | ||||
| WO2009077127A1 |
Other References:
QIU, Z. J. et al.,Journal of Immunological Methods,2010年,Vol.362,pp.101-111
Attorney, Agent or Firm:
Patent business corporation Tsukuni