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Title:
INTERLEUKIN-1-PRODUCING INHIBITOR
Document Type and Number:
Japanese Patent JPH07242599
Kind Code:
A
Abstract:

PURPOSE: To obtain an interleukin-1-producing inhibitor containing a 2- alkynylmalonic acid derivative as an active ingredient and useful for treating chronic rheumatism or inflammatory diseases.

CONSTITUTION: This interleukin-1-producing inhibitor contains a compound of the formula (R is H, an aryl, an aralkyl, a cycloalkyl, a cycloalkenyl, a lower alkyl, etc.; R1 is H or a carboxyl-protecting group; R2 is OH, a lower alkoxy, an amino, etc.) or its salt as an active ingredient. The compound of the formula has an activity close to prednisolone which is a conventional excellent steroidal compound and has inhibition activity equivalent to or higher than that of tenidap which is a nonsteroidal compound. The inhibitor is useful for arthrosis deformans, gout, atherosclerosis, atopic dermatitis, lung diseases accompanied by granuloma, various encephalitis, diabetes mellitus and osteoporosis and is effective also as immunosuppressive agent.


Inventors:
NAGAO YOSHIMITSU
SATO TOSHIO
Application Number:
JP6013194A
Publication Date:
September 19, 1995
Filing Date:
March 02, 1994
Export Citation:
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Assignee:
NAGAO YOSHIMITSU
SATO TOSHIO
International Classes:
A61K31/225; A61K31/255; A61K31/325; A61K31/34; A61K31/695; A61P29/00; A61P37/06; C07C69/732; C07C69/734; C07C229/12; C07C229/30; C07C233/47; C07C233/54; C07C271/22; C07D309/12; C07F7/10; (IPC1-7): C07C69/732; A61K31/225; A61K31/255; A61K31/325; A61K31/34; A61K31/695; C07C69/734; C07C229/12; C07C229/30; C07C233/47; C07C233/54; C07C271/22; C07D309/12; C07F7/10