Title:
制御性Ｔ細胞の増殖のためのインターロイキン－２変異タンパク質
Document Type and Number:
Japanese Patent JP7422480
Kind Code:
B2
Abstract:
Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.
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Inventors:
Butts, Eric Alan
Thomson, Christie Ann
Gavin, Marc Alan
Forz, Ian Nevin
Shea, Don
Alcorn, Dina N
Rim, Ai Chin
Ketchem, Rundle Robert
Manchurenko, cathy
Sekirov, Laura
Berry, kelly anne
De Imus, Seal Clovis Chua
Negra Jagdish, Agrawar
Canaan, Gunasekaran
Lee
Thomson, Christie Ann
Gavin, Marc Alan
Forz, Ian Nevin
Shea, Don
Alcorn, Dina N
Rim, Ai Chin
Ketchem, Rundle Robert
Manchurenko, cathy
Sekirov, Laura
Berry, kelly anne
De Imus, Seal Clovis Chua
Negra Jagdish, Agrawar
Canaan, Gunasekaran
Lee
Application Number:
JP2017553119A
Publication Date:
January 26, 2024
Filing Date:
May 04, 2016
Export Citation:
Assignee:
Amjien Incorporated
International Classes:
C07K14/55; A61K38/20; A61P3/10; A61P9/10; A61P11/06; A61P15/06; A61P17/00; A61P17/06; A61P17/14; A61P19/02; A61P29/00; A61P37/06; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/0783; C12N5/10; C12N15/26; C12P21/02
Domestic Patent References:
| JP2011519882A |
Foreign References:
| WO2014153111A2 | ||||
| WO2014153063A1 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office