Title:
インターロイキンおよびTNFの阻害剤としてのアミノベンゾフェノン類
Document Type and Number:
Japanese Patent JP4250204
Kind Code:
B2
Abstract:
The compounds of the present invention are represented by general formula (I) in which formula R1 and R2 stand independently for one or more, similar or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, alkyl, alkoxy, alkylthio, alkylamino, or alkoxycarbonyl, the C-content of which can be from 1 to 5, cyano, carboxy, carbamoyl, phenyl, or nitro; R3 stands for hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, alkyl, alkoxy, alkylthio, alkylamino, or alkoxycarbonyl, the C-content of which can be from 1 to 5, phenyl, cyano, carboxy, or carbamoyl; R4, R5 and R6 stand independently for hydrogen, trifluoromethyl, alkyl, carbamoyl, alkoxycarbonyl, or alkyloxo, the C-content of which can be from 1 to 5; X stands for oxygen, N-OH, N-O-alkyl, dialkoxy, cyclic dialkoxy, dialkylthio, or cyclic dialkylthio, the C-content of which can be from 1 to 5. The present compounds are of value in the human and veterinary practice as systemic and topical therapeutic agents for the treatment and prophylaxis of asthma, allergy, rheumatoid arthritis, spondyloarthritis, gout, atherosclerosis, chronic inflammatory bowel disease, proliferative and inflammatory skin disorders, such as psoriasis, and atopic dermatitis.
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Inventors:
Otsen, Eric Ritter
Lacrine, scnea
Lacrine, scnea
Application Number:
JP53149998A
Publication Date:
April 08, 2009
Filing Date:
January 08, 1998
Export Citation:
Assignee:
Leo Pharmaceutical Products Limited Actiesel Scab (Lebens Chemisque Fabric Production Actiesl Scab)
International Classes:
A61P1/00; A61K31/135; C07C225/22; A61K31/136; A61K31/167; A61K31/27; A61P9/10; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P29/00; C07C229/18; C07C229/56; C07C229/60; C07C233/43; C07C251/48; C07C255/58; C07C271/28; C07C275/40; C07C311/08; C07C311/21; C07C323/31
Other References:
Chemical Abstacts,vol.45,abs.no.9031b-i,9032a-e
Attorney, Agent or Firm:
Aoyama Aoi
Yasuo Shibata
Yasuo Shibata