INTERMEDIATE COMPOUND, METHOD FOR PRODUCING THE SAME, AND METHOD FOR PRODUCING ANSAMYCIN-BASED ANTIBIOTIC

Title:

INTERMEDIATE COMPOUND, METHOD FOR PRODUCING THE SAME, AND METHOD FOR PRODUCING ANSAMYCIN-BASED ANTIBIOTIC

Document Type and Number:

Japanese Patent JP2009191000

Kind Code:

A

Abstract:

To establish the total synthesis method of cytotrienin A, to provide an intermediate compound for synthesizing an ansamycin-based antibiotic comprising the cytotrienin A, to provide a method for producing the intermediate compound, and to provide a method for producing the ansamycin-based antibiotic.

The cytotrienin A is divided into four segments of a C1-C6 segment, a C7-C16 segment, a cyclopropanecarboxylic acid, and an aromatic segment, and the segments are linked, respectively to synthesize the cytotrienin A. A triene is constructed from a compound represented by formula (g) by a ring-closing metathesis reaction, and the protecting groups are then removed, particularly in the final stage of the synthesis.

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Inventors:

HAYASHI YUJIRO
OSADA HIROYUKI
KAKEYA HIDEAKI

Application Number:

JP2008032312A

Publication Date:

August 27, 2009

Filing Date:

February 13, 2008

Export Citation:

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Assignee:

UNIV OF SCIENCE TOKYO
RIKAGAKU KENKYUSHO

International Classes:

C07D407/04; C07C59/58; C07C309/68; C07D225/06; C07D307/40; C07F7/18

Attorney, Agent or Firm:

Masayuki Masabayashi

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