INTERMEDIATE COMPOUND FOR PRODUCING DIACYL-SUBSTITUTED GUANIDINE

Japanese Patent JP3775730

B2

PROBLEM TO BE SOLVED: To provide an intermediate compound for producing a diacyl- substituted guanidine useful as a Na+/H+ exchange inhibitor.
SOLUTION: This intermediate compound is a compound of the formula III [wherein, X(2) is a group as shown in the formula (a)]. As an example of the compound of the formula III, 4-isopropyl-3-methylsulfonylbenzoylguanidine and 4-fluoro-3-trifluoromethylbenzoylguanidine are cited. As the method for producing them, a method of reacting an acid chloride of a corresponding benzoic acid with guanidine hydrochloride in the presence of a base is exemplified. The diacylguanidine used as a medicine is obtained by reacting the compound of the formula III with a prescribed benzoic acid derivative.

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Heinz-Werner Kleman
Hans-Yohen Lang
Andreas Wueichert
Peter Clause
Wolfgang Schjorz
Oud Arbus

JP2001224010A

May 17, 2006

August 23, 1994

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Hoechst Gesellschaft Mito Beschlenktel Haftung

A61K31/185; A61K31/155; A61P9/00; C07C279/22; A61P9/10; C07C277/08; C07C279/20; C07C311/37; C07C311/59; C07C315/04; C07C317/32; C07C317/44; C07C323/65; C07C323/67; C07D207/327; C07D215/54; C07D231/12; C07D233/60; C07D233/61; C07D295/10; C07D295/155; C07D521/00; (IPC1-7): C07C279/22; C07D233/60; C07D295/10

JP8188568A
JP8073427A
JP7089938A
JP6345643A
JP6256291A
JP6239828A
JP6234727A
JP6228082A
JP6116230A
JP6009545A
JP3106858A
JP8511243A

Chika Takagi
Kosuke Nishimura

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