Title:
INTERMEDIATE FOR PRODUCING 14-DIHYDRO-4-OXO-QUINOLINE-3-CARBOXYLIC ACID, ESTER
Document Type and Number:
Japanese Patent JPH0217147
Kind Code:
A
Abstract:
NEW MATERIAL: Compounds given by formula I [Y is OR1 (R1 is H or 1-4C alkyl), Cl, CH3, formula II (R2 is 1-4C alkyl), formula III (R3=R2) or formula IV; X is F, Cl, or Br; when Y is OH, X ≠ Br, when Y is CH3, X ≠ F is excluded; only when R2 is CH3, X=F].
EXAMPLE: 2-Chloro-4,5-difulorobenzoic acid.
USE: A medicament. An intermediate for the production of 1-cyclopropyl-6- fluoro-1,4-dihydro-4-oxo-7-substituted-quinolne-3-carboxylic acid useful for curing bacteria infectious disease of mammal.
PROCESS: For example, a compound of formula V is acetylated in Fridel-Crafts conditions to prepare acetophenone of formula VI, which is oxidized with potassium permanganate, etc., to obtain a compound of formula I in which Y is OR1, and R1 is H.
Inventors:
FURANKU AARU BUTSUSHIYU
SUKOTSUTO JIEI HETSUKAA
POORU AARU MAKUGIIKU
BURAIAN TEII ONIIRU
HARII EI WATOSON JIYUNIAA
SUKOTSUTO JIEI HETSUKAA
POORU AARU MAKUGIIKU
BURAIAN TEII ONIIRU
HARII EI WATOSON JIYUNIAA
Application Number:
JP12653189A
Publication Date:
January 22, 1990
Filing Date:
May 19, 1989
Export Citation:
Assignee:
PFIZER
International Classes:
C07C45/00; C07C45/46; C07C49/807; C07C55/02; C07C63/70; C07C67/00; C07C69/76; C07C205/12; C07C69/738; C07C205/58; C07C227/02; C07C227/08; C07C229/34; C07C229/56; C07C245/20; C07C259/14; C07D215/56; (IPC1-7): C07C49/807; C07C63/70; C07C69/738; C07C69/76; C07C227/02; C07C227/08; C07C229/34; C07C229/56
Domestic Patent References:
| JPS61122272A | 1986-06-10 | |||
| JPS62108839A | 1987-05-20 | |||
| JPS62167768A | 1987-07-24 | |||
| JPS62246541A | 1987-10-27 | |||
| JPS6445332A | 1989-02-17 |
Attorney, Agent or Firm:
Kyozo Yuasa (4 outside)
Next Patent: PRODUCTION OF PYRUVIC ACID