PURPOSE: To obtain an intermediate for producing novel steroids having a 10-substituent and antiglucocorticoid activity and used for therapy or the like of the hypertension, glaucoma, atherosclerosis, osteoporosis, diabetes, immune depression, inflammatory diseases or the like.
CONSTITUTION: This intermediate is an intermediate for producing a novel 10-substituted steroid expressed by formula I [when X is methylene, R is a (substituted) carbocyclic or a heterocyclic aryl, a (substituted) vinyl or ethynyl, or when X is S or a single bond, R is a (substituted) carbocyclic or heterocyclic aryl; R2 is methyl or ethyl; K is a protecting group for ketone functional groups; K2 is a (protected) ketone functional group or a group expressed by formula II (R3 is a ≤3C alkyl, an alkenyl or an alkynyl)], having extraordinary antiglucocorticoid activity and used for curing or the like of inflammatory diseases. The compound is obtained by a method of reacting a compound of formula III (R4' is H or an OH-protecting group) with a lithium compound, or the like of the formula R-X-Li or the like.
JIERUMAN KOSUTORUUSU
BESUPERUTO TORERI
DANIERU FUIRIBEERU
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