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Title:
INTERMEDIATE USEFUL FOR SYNTHESIS OF CEFDINIR AND METHOD FOR PRODUCING CEFDINIR USING THE SAME
Document Type and Number:
Japanese Patent JP2009249380
Kind Code:
A
Abstract:

To provide a new intermediate compound effectively usable in producing cefdinir, and a method for effectively producing the cefdinir using the same.

Provided is the method for producing a cefdinir of general formula (7) characterized by comprising (a) a process of producing a compound of general formula (1) by reacting a compound of general formula (4) with an activating agent of general formula (5), (b) a process of producing a compound of general formula (2) by coupling the compound of general formula (1) produced in the process (a) with a compound of general formula (6), and then adding a secondary amine or a tertiary amine as a base to produce a compound of general formula (2), and (c) a process of reacting the compound of general formula (2) produced in the process of (b) under weakly basic conditions.


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Inventors:
KIM SUNHO
SONG YOON SEOK
LEE SUNG JAE
KIM FUNSOBU
MOON SEONG CHEOL
Application Number:
JP2009088796A
Publication Date:
October 29, 2009
Filing Date:
April 01, 2009
Export Citation:
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Assignee:
DAE WOONG PHARMA
DAEWOONG BIO INC
International Classes:
C07F9/165; C07D501/22
Domestic Patent References:
JPH1059978A1998-03-03
JP2000502700A2000-03-07
JPH1059978A1998-03-03
JP2006501305A2006-01-12
JP2000502700A2000-03-07
Foreign References:
WO2005121154A12005-12-22
Other References:
JPN6012006377; Liebigs Annalen No.11, p.1743-1749 (1996).
JPN6012006379; The Journal of Antibiotics Vol.44, No.5, p.507-516 (1991).
Attorney, Agent or Firm:
Norio Saeki