Title:
INTERPHENYLENEE99THIAA111OXOO122AZAPROSTANIC ACID
Document Type and Number:
Japanese Patent JPS5481267
Kind Code:
A
Abstract:
This invention provides novel interphenylene 9-this-11-oxo-12-azaprostanoic acid compounds and salts and other derivatives thereof. These compounds are exceptionally potent renal vasodilators and antihypertensives which are active when administered orally but which have a more specific type of bilogical activity than that of many of the natural prostaglandins and their synthetic analogs or derivatives. They are therefore made into pharmaceutical compositions.
The compounds have the formula:
where R is caboxy or a carboxy ester or amide. A is a monocyclic ring, n is 3 or 4; m is 0, 1 or 2; R<1> is hydrogen, deuterium, or methyl, Z ic a C2-3 chain, R<2> is hydrogen or alkanoyl, R<3> is hydrogen or alkyl and R<4> is an optionally substituted aliphatic hydrocarbon radical or R<3> and R<4> form a ring. Certain of the above definitions are broader than those in the specification.
Inventors:
EDOWAADO JIESURO KURAGOO JIYUN
TAAJIYA RII
JIYON BII BITSUKINGU
TAAJIYA RII
JIYON BII BITSUKINGU
Application Number:
JP13171778A
Publication Date:
June 28, 1979
Filing Date:
October 27, 1978
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
C07D327/04; A61K9/48; A61K31/425; A61K31/426; A61K31/557; A61K31/559; A61P9/08; A61P9/12; C07C29/62; C07C405/00; C07D277/04; C07D277/32; C07D309/12; C07D317/16; C07D317/30; C07D333/24; C07D333/38; C07D409/04; C07D417/06; C07D277/14; A61K; C07C; C07D; (IPC1-7): A61K31/425; C07D277/14; C07D417/06