To obtain the subject administering agent effective for the prophylaxis and treatment of ischemic neurocyte apoptosis accompanied by cerebral ischemia by an effect of an embolism, etc., occurred at internal carotid artery, etc., especially the prophylaxis and treatment of vascular dementia caused by late neurocyte apoptosis by using theanine as an active ingredient.
This agent contains theanine as an active ingredient. Further, as the above theanine, an L- or D-glutamic acid-γ-alkylamide such as L-glutamic acid-γ-ethylamide (L-theanine), L-glutamic acid-γ-methylamide, D-glutamic acid-γ- ethylamide (D-theanine), etc., or their mixture are used, so as to make 50-800 μM, especially 50-500 μM theanine concentration. It is preferable to dissolve the theanine with an aqueous solution, a saline or the like as it is, and to add cardiocrome, etc., to the theanine aqueous solution.
NOZAWA AYUMI
UNNO TOMONORI
USHITANI KORO
KATAOKA KIYOSHI
YANASE NAOHITO
| JPH09286727A | 1997-11-04 | |||
| JPH101439A | 1998-01-06 | |||
| JPH10324626A | 1998-12-08 | |||
| JPH0827022A | 1996-01-30 |