Title:
乳房障害の治療の乳管内送達方法
Document Type and Number:
Japanese Patent JP2021506943
Kind Code:
A
Abstract:
本発明は、乳房障害を有する対象を治療するための乳管内送達方法及び組成物に関する。組成物は、腫瘍微小環境において、M2マクロファージをM1マクロファージに再分極化させ、M2マクロファージを減少させ、M1マクロファージを増加させ、及び/又は対象における化学療法に対する感受性を増加させることができる、再分極化剤及び分極化遮断剤を含む。
Inventors:
Stephen Sea Quay
Application Number:
JP2020534923A
Publication Date:
February 22, 2021
Filing Date:
December 20, 2018
Export Citation:
Assignee:
Atossa Therapeutics Incorporated
International Classes:
A61K45/00; A61K9/107; A61K9/127; A61K9/16; A61K9/51; A61K35/12; A61K38/20; A61K39/395; A61K41/00; A61K45/06; A61K47/69; A61K48/00; A61P15/00; A61P35/00; A61P43/00
Other References:
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ZHANG, X. ET AL.: "Hydrazinocurcumin Encapsuled nanoparticles "re-educate" tumor-associated macrophages and exhibit ant", PLOS ONE, vol. 8, no. 6, JPN6023000125, 2013, pages 65896, XP055376894, ISSN: 0004959530, DOI: 10.1371/journal.pone.0065896
CHIANG, C. F. ET AL.: "Metformin-treated cancer cells modulate macrophage polarization through AMPK-NF-κB signaling", ONCOTARGET, vol. 8, no. 13, JPN6023000126, 1 February 2017 (2017-02-01), pages 20706 - 20718, ISSN: 0004959531
TANG, X. ET AL.: "Anti-tumour strategies aiming to target tumour-associated macrophages", IMMUNOLOGY, vol. 138, no. 2, JPN6023000127, 2013, pages 93 - 104, XP055447644, ISSN: 0004959532, DOI: 10.1111/imm.12023
JOSEPHS, D. H. ET AL.: "Tumour-associated macrophage polarisation and re-education with immunotherapy", FRONTIERS IN BIOSCIENCE (ELITE EDITION), vol. 7, no. 2, JPN6023000128, 2015, pages 334 - 351, ISSN: 0004959533
STEARNS, V. ET AL.: "Preclinical and clinical evaluation of intraductally administered agents in early breast cancer", SCIENCE TRANSLATIONAL MEDICINE, vol. 3, no. 106, JPN6023000129, 2011, pages 106 - 108, XP055376192, ISSN: 0004959534, DOI: 10.1126/scitranslmed.3002368
LOVE, S. M. ET AL.: "A feasibility study of the intraductal administration of chemotherapy", CANCER PREVENTION RESEARCH (PHILADELPHIA, PA.), vol. 6, no. 1, JPN6023000130, 2013, pages 51 - 58, XP055778176, ISSN: 0004959535, DOI: 10.1158/1940-6207.CAPR-12-0228
ZHANG, B. ET AL.: "The safety parameters of the study on intraductal cytotoxic agent delivery to the breast before mast", CHINESE JOURNAL OF CANCER RESEARCH, vol. 26, no. 5, JPN6023000131, 2014, pages 579 - 587, ISSN: 0004959536
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe