Title:
アルブミンの内因的に形成された結合体
Document Type and Number:
Japanese Patent JP2008512385
Kind Code:
A
Abstract:
A conjugate formed in vivo and comprised of endogenous albumin and an amine-containing compound, such as a protein or a drug, is described. The conjugate is formed by in vivo cleavage of a polymer-dithiobenzyl-therapeutic agent conjugate to form an albumin-dithiobenzyl-therapeutic agent conjugate. The dithiol moiety of the albumin-therapeutic agent conjugate is cleaved in vivo to yield the free therapeutic agent in native form.
Inventors:
Hutchins, Maria, You.
Kiwan, Radwan
The Lipsky, Samuel
Kiwan, Radwan
The Lipsky, Samuel
Application Number:
JP2007530475A
Publication Date:
April 24, 2008
Filing Date:
August 31, 2005
Export Citation:
Assignee:
Alza Corporation
International Classes:
A61K47/48; A61K38/22; A61K38/46; A61K45/00; A61K47/34; A61P1/14; A61P7/06
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio