NEW MATERIAL:A radioactive iodine-labeled heptapeptide expressed by formula I.
USE: A tracer of a peptide expressed by formula II useful for the diagnosis of nervous of digestive tract diseases. The peptide expressed by formula II is a neurotransmitter having salivary secretion, depolarizing, intestinal contracting actions, etc., and the iodine-labeled heptapeptide expressed by formula I is capable of tracing the peptide expressed by formula II specifically in the radioimmunoassay (RIA).
PROCESS: A heptapeptide expressed by formula I is synthesized by the conventional fragment condensing method and stepwise method. The resultant heptapeptide expressed by formula I is labeled with radioactive iodine by the chloramine T method to give the iodine-labeled heptapeptide expressed by formula I. The radioactive iodine is preferably 125I.
KATOU TAKESHI
OGAWA HIROSHI
NAKAZAWA NOBUHIKO
| JPS53147065A | 1978-12-21 | |||
| JPS5225767A | 1977-02-25 | |||
| JPS5257174A | 1977-05-11 |