Title:
核酸送達のためのイオン化可能な脂質
Document Type and Number:
Japanese Patent JP7416096
Kind Code:
B2
Abstract:
The present document describes compounds, or pharmaceutically acceptable salt thereof, of a core formula (I) where R1 features an amine group, particularly useful in the formulation of lipid particles including nucleic acid therapeutic agents, or proteins, or both, and for delivery of nucleic acid and protein therapeutics to cells in vivo or ex vivo, including anticancer and vaccine applications.
Inventors:
Jane, Nikita
Thomas, Anita
Brown, Andrew William
Thomas, Anita
Brown, Andrew William
Application Number:
JP2021574974A
Publication Date:
January 17, 2024
Filing Date:
June 19, 2020
Export Citation:
Assignee:
Precision Nanosystems ULC
International Classes:
C07C229/12; A61K9/16; A61K9/51; A61K31/7088; A61K31/7105; A61K31/713; A61K35/17; A61K38/02; A61K39/00; A61K45/00; A61K47/10; A61K47/14; A61K47/18; A61K47/22; A61K47/28; A61P31/12; A61P35/00; A61P43/00; C07D205/04; C07D207/277; C07D211/62; C07D233/64
Domestic Patent References:
| JP3112939A | ||||
| JP2108647A | ||||
| JP53084943A | ||||
| JP2014001142A | ||||
| JP2011509258A |
Foreign References:
| WO2008109238A1 | ||||
| WO2019182527A1 |
Other References:
Advances in Genetics,2014年,88,71-110,DOI 10.1016/B978-0-12-800148-6.00004-3
Tetrahedron,2006年,62(37),8805-8813,DOI 10.1016/j.tet.2006.06.092
Chemistry & Biodiversity,2006年,3(6),654-659,DOI 10.1002/cbdv.200690068
Bioorganic & Medicinal Chemistry Letters,1998年,8(21),2961-2966,DOI 10.1016/S0960-894X(98)00532-0
Tetrahedron,2006年,62(37),8805-8813,DOI 10.1016/j.tet.2006.06.092
Chemistry & Biodiversity,2006年,3(6),654-659,DOI 10.1002/cbdv.200690068
Bioorganic & Medicinal Chemistry Letters,1998年,8(21),2961-2966,DOI 10.1016/S0960-894X(98)00532-0
Attorney, Agent or Firm:
Ikeda Adult
Junichiro Sakamaki
Masakazu Noda
Junichiro Sakamaki
Masakazu Noda