Title:
腫瘍および／または癌の処置のための医薬のための単離された組換え体腫瘍溶解性アデノウイルス、医薬組成物、およびそれらの使用
Document Type and Number:
Japanese Patent JP7159304
Kind Code:
B2
Abstract:
The present disclosure provides an isolated recombinant oncolytic adenovirus, a pharmaceutical composition, and uses thereof for drugs for treatment of tumors and/or cancers. The recombinant oncolytic adenovirus is a selectively replicating oncolytic adenovirus, and the genome of the recombinant oncolytic adenovirus is integrated with a coding sequence of exogenous shRNA capable of inhibiting PDL1 expression in tumor cells. The replication capability of the virus in normal primary cells is much lower than the replication capability of the virus in tumor cells. Moreover, the expressed shPDL1 can significantly reduce the level of PDL1 protein highly expressed in tumor cells. Thus, the oncolytic killing effect of the oncolytic virus and the anti-tumor immunostimulatory effect of immune cells produce a synergistic effect.
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Inventors:
Sion, Jipo
Hu, gin
Zhao, Ronfa
Jin, Yun
Chen, Lin
Kang, San Mao
Hoo, fan
Hu, gin
Zhao, Ronfa
Jin, Yun
Chen, Lin
Kang, San Mao
Hoo, fan
Application Number:
JP2020518660A
Publication Date:
October 24, 2022
Filing Date:
July 03, 2018
Export Citation:
Assignee:
HANGZHOU CONVERD CO.,LTD.
International Classes:
C12N15/861; A61K35/761; A61K48/00; A61P35/00; A61P35/02; C12N7/01; C12N15/113
Domestic Patent References:
| JP2007531519A | ||||
| JP2017522025A |
Foreign References:
| WO2017100127A1 | ||||
| WO2016177343A1 |
Other References:
Int. J. Mol. Med.,2013年02月,Vol.31, No.2,pp.377-385
Cancer Biology & Therapy,Vol.4, No.11,pp.1255-1262
Cancer Biology & Therapy,Vol.4, No.11,pp.1255-1262
Attorney, Agent or Firm:
Patent business corporation glory patent office
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