ISOLATION, SELECTION AND PROPAGATION OF ANIMAL TRANSGENIC STEM CELL

Title:

ISOLATION, SELECTION AND PROPAGATION OF ANIMAL TRANSGENIC STEM CELL

Document Type and Number:

Japanese Patent JP2007252387

Kind Code:

A

Abstract:

To provide a method of isolating and/or enriching and/or selectively propagating animal stem cells, genetically modified animal cells and animals used in the method, transgenic animals offering such cell resources as well as selectable marker constructs for production of the genetically modified animal cells and transgenic animals.

Animal stem cells are obtained and maintained by culturing cells containing a selectable marker in the genome. Peculiar expression of the selectable marker enables preferential survival and/or division of the desired stem cells compared to the non-stem cells. This selectable marker may be an antibiotic-resistant gene.

Inventors:

SMITH AUSTIN G
MOUNTFORD PETER S

Application Number:

JP2007139498A

Publication Date:

October 04, 2007

Filing Date:

May 25, 2007

Export Citation:

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Assignee:

UNIV COURT OF THE UNIV OF EDIN

International Classes:

C12N15/09; A01K67/02; A01K67/027; C07K14/47; C07K14/52; C07K14/705; C07K14/81; C12N5/0797; C12N5/10; C12N9/12; C12N15/12; C12N15/85; C12N15/873; C12N15/90; C12Q1/04; C12Q1/68; A61K38/00

Attorney, Agent or Firm:

Hiromichi Nanjo

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