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Title:
ISOMERIC DIDEOXYNUCLEOSIDE
Document Type and Number:
Japanese Patent JPH02235883
Kind Code:
A
Abstract:

NEW MATERIAL: A compound of formula I [wherein A is 6-amino-9H-purin-9- yl,2-amino-6-hydroxy-9H-purin-9-yl; provided that the amino group may be substituted by NHO(O)R2 and N=CHR3R4; R is OH, OC(O)R1; and R1 to R4 are each a 1-20C alkyl, a 1-12 alkoxyalkyl, a (substituted)phenyl or the like].

EXAMPLE: (3R-cis)-2-amino-1,9-dehydro-9-[tetrahydro-5-(hydroxymethyl)-3-furanyl]-6 H-purin-6-one.

USE: An agent for the treatment of a subject infected with a retrovirus.

PREPARATION: A compound represented by formula II (wherein X is an eliminable group; and C is hydroxylmethyl or a masked precursor) is reacted with adenine or guanine, and the masked precursor C is optionally converted into hydroxymethyl.


Inventors:
DONA MEARII FURIN
SUCHIIBU IKUUKAI TAMU
MANFUREETO BAIGERE
Application Number:
JP1990000028659
Publication Date:
September 18, 1990
Filing Date:
February 09, 1990
Export Citation:
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Assignee:
HOFFMANN LA ROCHE
International Classes:
C07H19/16; A61K31/52; A61K31/522; A61P31/12; C07D307/20; C07D307/22; C07D339/08; C07D405/04; C07D409/04; C07D473/00; C07D473/18; C07D473/34; C07H9/02; C07H13/00; C07H13/12; C07H15/26; C12P19/40; (IPC1-7): A61K31/52; C07D307/20; C07D473/18; C07D473/34; C07H9/02; C07H15/26