Title:
ISOMERIZATION OF PHARMACEUTICAL INTERMEDIATES
Document Type and Number:
Japanese Patent JP2013056898
Kind Code:
A
Abstract:
To produce vitamin D analogues.
The present invention relates to: an isomerization method of vitamin D analogues, such as compounds useful for the synthesis of calcipotriol; and the use of a flow-through photoreactor or continuous flow photoreactor reactor for synthesizing the vitamin D analogues. The present invention relates further to the use of intermediates synthesized with the method, so that calcipotriol or calcipotriol monohydrate, or pharmaceutical formulations thereof are produced.
Inventors:
FOLKMANN MICHAEL PETER
HANSEN ERIK TORNGAARD
HANSEN ERIK TORNGAARD
Application Number:
JP2012231150A
Publication Date:
March 28, 2013
Filing Date:
October 18, 2012
Export Citation:
Assignee:
LEO PHARMA AS
International Classes:
C07C401/00; A61K9/06; A61K31/592; A61P17/06; C07B61/00
Domestic Patent References:
| JP2001163856A | 2001-06-19 | |||
| JPH08505612A | 1996-06-18 |
Foreign References:
| WO1996035508A1 | 1996-11-14 |
Other References:
JPN6011067000; ＣＡＬＶＥＲＬＥＹ Ｍ Ｊ: 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ＭＣ ９０３， Ａ Ｂｉｏｌｏｇｉｃａｌｌｙ Ａｃｔｉｖｅ Ｖｉｔａｍｉｎ Ｄ Ｍｅｔａｂｏｌｉｔｅ Ａｎａｌｏｇｕｅ' Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．４３， Ｎｏ．２０, 1987, ｐｐ．４６０９-４６１９
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Sakurai Yoko
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Sakurai Yoko