Title:
ＨＰＫ１阻害剤としてのイソキノリン
Document Type and Number:
Japanese Patent JP7129420
Kind Code:
B2
Abstract:
Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.
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Inventors:
Chan, Brian
Drobnik, Joy
Gazzard, Lewis
Heflon, Timothy
Liang, Jun
Malhotra, Shunt
Mendonza, Rohan
Rajapaksa, Naomi
Stibara, Craig
Terris, John
One, Waylou
Way, Bin Chin
Chow, Aihe
Cartwright, Matthew W.
rain berry, michael
Gantia, Emanuela
Seward, Eileen
Madden, Andrew
Faber, David
Huong, Kin Chiu
Hu, Younghan
Good, Andrew
Drobnik, Joy
Gazzard, Lewis
Heflon, Timothy
Liang, Jun
Malhotra, Shunt
Mendonza, Rohan
Rajapaksa, Naomi
Stibara, Craig
Terris, John
One, Waylou
Way, Bin Chin
Chow, Aihe
Cartwright, Matthew W.
rain berry, michael
Gantia, Emanuela
Seward, Eileen
Madden, Andrew
Faber, David
Huong, Kin Chiu
Hu, Younghan
Good, Andrew
Application Number:
JP2019553484A
Publication Date:
September 01, 2022
Filing Date:
March 30, 2018
Export Citation:
Assignee:
Ef Hoffman-La Roche Akchengezel Shaft
International Classes:
C07D217/22; A61K31/472; A61K31/4725; A61K31/4985; A61K31/501; A61K31/506; A61K31/5377; A61K31/5383; A61K31/542; A61K31/55; A61K31/5517; A61K31/554; A61K45/00; A61P35/00; A61P37/04; A61P43/00; C07D401/04; C07D401/14; C07D407/14; C07D413/04; C07D413/14; C07D417/04; C07D471/04; C07D487/04; C07D487/10; C07D487/14; C07D498/04; C07D513/04; C07D519/00
Domestic Patent References:
| JP2013523715A |
Foreign References:
| US20100331328 | ||||
| WO2016205942A1 |
Other References:
LINNEY, Ian D.,Expert Opinion on Therapeutic Patents,2021年,31(10),893-910
Attorney, Agent or Firm:
Sonoda & Kobayashi Patent Attorneys Corporation