ISOTHIAZOLE DIOXIDE AS CXC-CHEMOKINE RECEPTOR LIGAND AND CC-CHEMOKINE RECEPTOR LIGAND

Title:

ISOTHIAZOLE DIOXIDE AS CXC-CHEMOKINE RECEPTOR LIGAND AND CC-CHEMOKINE RECEPTOR LIGAND

Document Type and Number:

Japanese Patent JP2011098984

Kind Code:

A

Abstract:

To provide a compound capable of controlling activity in a CXC-chemokine receptor.

There are disclosed novel compounds of formula (IA), and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising substituent B include aryl and heteroaryl. Also there is disclosed a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.

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Inventors:

TAVERAS ARTHUR G
ZHENG JUNYING
BIJU PURAKKATTLE J
YU YOUNONG
CHAO JIANHUA
FINE JAY
LUNDELL DANIEL
PRIESTLEY TONY
REGGIANI ANGELO
MERRITT J ROBERT
BALDWIN JOHN J
LAI GAIFA
WU MINGLANG

Application Number:

JP2011030287A

Publication Date:

May 19, 2011

Filing Date:

February 15, 2011

Export Citation:

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Assignee:

SCHERING CORP
PHARMACOPEIA DRUG DISCOVERY

International Classes:

C07D417/12; A61K31/427; A61K45/00; A61P1/02; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P5/00; A61P7/02; A61P7/06; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P11/14; A61P11/16; A61P13/10; A61P13/12; A61P15/06; A61P17/02; A61P17/04; A61P17/06; A61P17/14; A61P19/02; A61P19/06; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/04; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/04; A61P31/12; A61P31/18; A61P31/20; A61P31/22; A61P33/06; A61P35/00; A61P37/06; A61P37/08; C07D275/03; C07D417/14; C07D275/02

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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